Inveni Capital invests in Lx Therapies
Ark grants VEGF genes licence to Oy Lx Therapies Ltd for lymphatic disease
* January 2009 - Ark Therapeutics Group plc ('Ark' or 'the Company') today announces that it has granted an exclusive sublicence to the Finnish company, Oy Lx Therapies Ltd (‘Lx Therapies’), for the use of VEGF-C and VEGF-D genes in lymphatic disease. Ark has also granted Lx Therapies a licence to use its proprietary adenoviral vector gene-medicine manufacturing processes and knowhow in gene therapy to deliver the genes. In return, Ark has received an equity holding of 5% in Lx Therapies and will also receive a single digit royalty on the net sales of any marketed product.
Lx Therapies, founded in 2008, is a drug discovery company focused on developing genemediated therapies for the prevention and treatment of diseases of lymphatic vasculature. The initial focus of the company is on breast cancer-related lymphoedema, a relatively common complication of breast cancer treatment for which there is currently no cure or effective treatment. Lx Therapies, based in Helsinki, has received a EUR 2 million investment from Inveni Capital, the Finnish-German life sciences venture fund and a founder of Lx Therapies.
Under the terms of the licence, Ark will supply Lx Therapies with batches of adenovirus VEGF-C and adenovirus VEGF-D for research purposes. Subject to capacity, Ark has agreed to supply Lx Therapies with clinical batches at a commercial rate in due course.
The intellectual property to the genes being sublicensed to Lx Therapies was originally acquired by Ark through the purchase of Lymphatix Oy, in January 2008. That acquisition gave Ark exploitation rights to the vascular endothelial growth factor genes known as VEGF-C and VEGF-D for developing gene-based medicines in the angiogenesis and lymphangiogenesis areas. Ark already had VEGF-based programmes in pre-clinical development in these areas, notably refractory angina, wound healing, prevention of restenosis and foetal growth restriction. Results to date have shown that VEGF plays a key role in these diseases.
Dr Nigel Parker, Chief Executive Officer of Ark, commented: “This licence will allow Ark to take advantage of Lx Therapies’ expertise in lymphatic disease and to use their focus in this area to optimise development. Lymphoedema is an extremely common disorder following cancer-related removal of the lymph gland and is an area of high clinical need. We look forward to working closely together with Lx Therapies and to moving this next area of gene-based medicines towards the clinic.”
Professor Markku Jalkanen, Chairman of Lx Therapies and Partner of Inveni Capital, added: “This is an important agreement for us as it gives us access not only to the most suitable growth factors for the purpose but also to the expertise and resources of Ark in the field of gene-mediated therapies. Having a leading gene therapy company as a partner is a great benefit to us in developing Lx Therapies into a leading biotech company in the field of diseases of lymphatic vasculature.”
Enquiries:
Ark Therapeutics Group plc +44 (0)20 7388 7722
Dr Nigel Parker, Chief Executive Officer
Martyn Williams, Chief Financial Officer
Financial Dynamics +44 (0)20 7831 3113
David Yates/Lara Mott
Oy Lx Therapies Ltd
Markku Jalkanen, Chairman +358 (0)40 520 6124
Notes to Editors
About Ark Therapeutics Group plc
Ark Therapeutics Group plc is a specialist healthcare group (the "Group") addressing high value
areas of unmet medical need within vascular disease, wound care and cancer. These are large
and growing markets, where opportunities exist for effective new products to generate significant
revenues. With four marketed devices, Kerraboot®, Kerraped®, Flaminal® and Neuropad®, and
three further lead pharmaceutical products in late stage clinical development: Cerepro®, Vitor™,
and Trinam®, the Group is transitioning from an R&D company to a commercial, revenue
generating business.
Ark's own products are sourced from related but largely non-dependent technologies within the
Group and have been selected to enable them to be taken through development within the Group's
own means and to benefit from Orphan Drug Status and/or Fast Track Designation, as
appropriate. This strategy has allowed the Group to retain greater value and greater control of
clinical development timelines, and to mitigate the risks of dependency on any one particular
programme or development partner. Ark has secured patents or has patent applications pending
for all its lead products in principal pharmaceutical markets.
Ark has its origins in businesses established in the mid-1990s by Professor John Martin and Mr
Stephen Barker of University College London and Professor Seppo Yla-Herttuala of the AI Virtanen
Institute at the University of Kuopio, Finland, all of whom play leading roles in the Company's
research and development programmes.
Ark's shares were first listed on the London Stock Exchange in March 2004 (AKT.L).
About Inveni Capital
Inveni Capital, established in 2007 and with offices in Finland and Germany, is a venture capital
management company with some € 30 million under management investing in early to growth–
stage life science (pharma and medtech) companies in Northern and Central Europe. Inveni
Capital, with its experienced team, is a highly engaged investor in its portfolio companies.
About Lymphatix Oy
Lymphatix Oy was founded in 2003 by the Ludwig Institute for Cancer Research, Licentia
Ltd/Helsinki University and a number of Finnish and Australian academics, including Associate
Professor Marc Achen, Professor Kari Alitalo, Dr Marika Karkkainen, Associate Professor Steven
Stacker and Professor Seppo Yla-Herttuala.
About Oy Lx Therapies Ltd
Lx Therapies, founded in 2008, is a drug discovery company focused on developing genemediated
therapies for the prevention and treatment of diseases of lymphatic vasculature. The
initial focus of the company is on breast cancer-related lymphoedema, a relatively common
complication of breast cancer treatment for which there is no cure or effective treatment today.
This announcement includes "forward-looking statements" which include all statements other than statements of historical facts,
including, without limitation, those regarding the Group's financial position, business strategy, plans and objectives of management for
future operations (including development plans and objectives relating to the Group's products and services), and any statements
preceded by, followed by or that include forward-looking terminology such as the words "targets", "believes", "estimates", "expects",
"aims", "intends", "will", "can", "may", "anticipates", "would", "should", "could" or similar expressions or the negative thereof. Such
forward-looking statements involve known and unknown risks, uncertainties and other important factors beyond the Group's control that
could cause the actual results, performance or achievements of the Group to be materially different from future results, performance or
achievements expressed or implied by such forward-looking statements. Such forward-looking statements are based on numerous
assumptions regarding the Group's present and future business strategies and the environment in which the Group will operate in the
future. Among the important factors that could cause the Group's actual results, performance or achievements to differ materially from
those in forward-looking statements include those relating to Ark's funding requirements, regulatory approvals, clinical trials, reliance on
third parties, intellectual property, key personnel and other factors. These forward-looking statements speak only as at the date of this
announcement. The Group expressly disclaims any obligation or undertaking to disseminate any updates or revisions to any forwardlooking
statements contained in this announcement to reflect any change in the Group's expectations with regard thereto or any change
in events, conditions or circumstances on which any such statements are based. As a result of these factors, readers are cautioned not
to rely on any forward-looking statement.
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